Nam Hoon Kwon Selected Research

Lysine-tRNA Ligase

6/2021	Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis.
11/2018	Lysyl-tRNA synthetase-expressing colon spheroids induce M2 macrophage polarization to promote metastasis.
4/2016	Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell‑extracellular matrix adhesion for migration.
2/2016	Erratum: Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.
8/2015	Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.
1/2014	Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction.

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Nam Hoon Kwon Research Topics

Disease

19	Neoplasms (Cancer) 06/2021 - 03/2011
5	Neoplasm Metastasis (Metastasis) 06/2021 - 01/2014
4	Colonic Neoplasms (Colon Cancer) 11/2018 - 08/2015
3	Breast Neoplasms (Breast Cancer) 01/2021 - 01/2018
2	Inflammation (Inflammations) 01/2020 - 01/2019
2	Lung Neoplasms (Lung Cancer) 01/2020 - 01/2017
2	Infections 01/2017 - 10/2016
1	Pathologic Constriction (Stenosis) 10/2021
1	Bile Duct Neoplasms (Bile Duct Cancer) 01/2020
1	Adenocarcinoma 01/2020
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2019
1	Lymphatic Metastasis 11/2019
1	Starvation 01/2018
1	Glioblastoma (Glioblastoma Multiforme) 03/2016
1	Parasitic Diseases (Parasitic Disease) 09/2015
1	Carcinogenesis 03/2011
1	Glomerulonephritis 03/2010
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 03/2010
1	Proteinuria 03/2010
1	Staphylococcal Food Poisoning 06/2007
1	Respiratory Tract Diseases (Respiratory Tract Disease) 11/2006
1	Bovine Mastitis 03/2004
1	Mastitis 03/2004

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2011
6	Methionine-tRNA LigaseIBA 10/2021 - 12/2011
6	Lysine-tRNA LigaseIBA 06/2021 - 01/2014
4	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA 01/2020 - 03/2011
3	Transfer RNA (tRNA)IBA 01/2021 - 01/2014
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2020
3	Pharmaceutical PreparationsIBA 10/2020 - 09/2015
3	GelsIBA 11/2018 - 08/2015
2	AntibodiesIBA 01/2020 - 03/2010
2	Ligases (Synthetase)IBA 01/2019 - 01/2014
2	Laminin (Merosin)IBA 11/2018 - 01/2014
2	Tryptophan-tRNA LigaseIBA 01/2017 - 10/2016
2	CollagenIBA 02/2016 - 08/2015
2	Monoclonal AntibodiesIBA 11/2006 - 03/2004
2	Differentiation AntigensIBA 11/2006 - 03/2004
1	PyridinesIBA 06/2021
1	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2021
1	PF-562271IBA 01/2021
1	Messenger RNA (mRNA)IBA 01/2020
1	Matrix Metalloproteinases (MMPs)IBA 01/2020
1	Multifunctional EnzymesIBA 01/2019
1	CytokinesIBA 01/2019
1	MicroRNAs (MicroRNA)IBA 01/2019
1	Macrophage Colony-Stimulating FactorIBA 11/2018
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 11/2018
1	Cyclin-Dependent Kinase 4IBA 09/2018
1	Leu Transfer RNAIBA 01/2018
1	Ribosomal Proteins (Ribosomal Protein)IBA 01/2018
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 01/2018
1	Amino Acids FDA Link 01/2018
1	MTOR InhibitorsIBA 01/2017
1	Sirolimus (Rapamycin)FDA Link 01/2017
1	AutoantibodiesIBA 01/2017
1	Fluorouracil (Carac)FDA LinkGeneric 03/2016
1	Transcription Factors (Transcription Factor)IBA 01/2016
1	RNA (Ribonucleic Acid)IBA 01/2016
1	quinolineIBA 09/2015
1	compound 21IBA 09/2015
1	Laminin ReceptorsIBA 01/2014
1	EnzymesIBA 01/2014
1	CarcinogensIBA 03/2011
1	DNA (Deoxyribonucleic Acid)IBA 03/2010
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 03/2010
1	SuperantigensIBA 06/2007
1	spleen fibrinolytic proteinase (human) (SFP)IBA 06/2007
1	B-Cell Antigen Receptors (B Cell Antigen Receptors)IBA 11/2006
1	PhytohemagglutininsIBA 11/2006
1	AntigensIBA 03/2004